Peptide Libraray

H14

General Information

DCTPep ID DCTPep01531

Peptide Name H14

Sequence RVKLVNLXFATLREXVP

Sequence Length 17

UniProt ID Not available

PubChem CID Not available

Origin Synthetics

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
NCI-H187	Lung small cell carcinoma; Small cell lung cancer	EC50≈10 μM	MTT assay	Not available	Patent
NCI-H510A	Lung small cell carcinoma; Small cell lung cancer	EC50≈12 μM	MTT assay	Not available	Patent
NCI-H524	Lung small cell carcinoma; Small cell lung cancer	EC50≈12.5 μM	MTT assay	Not available	Patent
NCI-H82	Lung small cell carcinoma; Small cell lung cancer	EC50≈12.5 μM	MTT assay	Not available	Patent
HL-60	Adult acute myeloid leukemia; Acute myeloid leukemia	EC50≈14 μM	MTT assay	Not available	Patent
GBM-18	Glioblastoma	EC50≈4 μM	MTT assay	Not available	Patent
GBM-27	Glioblastoma	EC50≈5 μM	MTT assay	Not available	Patent
NCI-H69	Lung small cell carcinoma; Small cell lung cancer	EC50≈7 μM	MTT assay	Not available	Patent
MCF-7	Invasive breast carcinoma of no special type	EC50≈9 μM	MTT assay	Not available	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification X=—(CH2)6—CH═CH—(CH2)3— (for the cases NS10, NS16 and Na05) links both Xs radicals in each sequence

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US 2021/0230226 A1

Patent Title Anticancer Peptides

Other Iinformation Patent Application; Family: 8s / 8ex; Family Jurisdictions: CN, EP, CA, JP, AU, WO, US, KR; Legal Status: Pending; Application No: 201816634067; Filed: Jul 24, 2018; Published: Jul 29, 2021; Earliest Priority: Jul 25, 2017

Other Published ID AU2018305923A1 CA3070874A1 CN111263768A EP3658576A1 JP2020528458A KR20200032183A WO2019020649A1