Peptide Libraray

Nal2-S1

General Information

DCTPep ID DCTPep01591

Peptide Name Nal2-S1

Sequence XXKKWRKWLAKK

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Cationic antimicrobial peptides (CAMPs)

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
PC-9	Lung adenocarcinoma	When the peptide concentrations was 25μM, the Cell survival rate(%) was 0%	MTT assay	3 h	Patent
PC-9G	Lung adenocarcinoma	When the peptide concentrations was 25μM, the Cell survival rate(%) was 0%	MTT assay	3 h	Patent
A549	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	3 h	Patent
A549	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	12 h	Patent
OECM-1	Gingival squamous cell carcinoma; Squamous cell carcinoma of the oral cavity	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	3 h	Patent
OECM-1	Gingival squamous cell carcinoma; Squamous cell carcinoma of the oral cavity	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	12 h	Patent
OECM-1	Gingival squamous cell carcinoma; Squamous cell carcinoma of the oral cavity	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	24 h	Patent
PC-9	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	12 h	Patent
PC-9	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	24 h	Patent
PC-9G	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	12 h	Patent
PC-9G	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 0%	MTT assay	24 h	Patent
A549	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 1%	MTT assay	24 h	Patent
PC-9	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 1%	MTT assay	3 h	Patent
SAS	Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue	When the peptide concentrations was 50μM, the Cell survival rate(%) was 1%	MTT assay	3 h	Patent
PC-9	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 10%	MTT assay	24 h	Patent
SAS	Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue	When the peptide concentrations was 50μM, the Cell survival rate(%) was 2%	MTT assay	24 h	Patent
PC-9	Lung adenocarcinoma	When the peptide concentrations was 50μM, the Cell survival rate(%) was 72%	MTT assay	12 h	Patent
SAS	Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue	When the peptide concentrations was 50μM, the Cell survival rate(%) was 72%	MTT assay	12 h	Patent

Hemolytic Activity human red blood cells: Nal2-S1 peptide displayed 10% hemolytic activity at 25 μM peptide concentration

Normal (non-cancerous) Cytotoxicity human fibroblast: When the peptide concentrations was 100μM, the Cell survival rate(%) was 1%

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Acetylization

C-terminal Modification Amidation

Other Modification X=Nal, β-naphthylalanine

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US10093699B2

Patent Title Peptides with antimicrobial, anticancer and/or wound-healing promoting activities, pharmaceutical compositions containing the same, and use of the peptides with antimicrobial, anticancer and/or wound-healing promoting activities

Other Iinformation Granted Patent; Family: 4s / 4ex; Family Jurisdictions: TW, US; Legal Status: Active; Application No: 201615130709; Filed: Apr 15, 2016; Published: Oct 9, 2018; Earliest Priority: Nov 5, 2015; Granted: Oct 9, 2018

Other Published ID TW201716428A TWI619731B US10093699B2