This work is licensed under a Creative Commons Attribution 4.0 International License.
peptide4
General Information
DCTPep ID DCTPep01596
Peptide Name peptide4
Sequence FLSGIVGMLaKLF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin analogs of antimicrobial peptide temporin-SHa
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=16.2 ± 2.2 μM | MTT assay | 24 h | Patent |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=22.7 ± 0.86 μM | MTT assay | 24 h | Patent |
| NCI-H460 | Lung large cell carcinoma | IC50=24.3 ± 0.84 μM | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=16.02 ± 3.7 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification a=D-alanine
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US10550155B2
Patent Title Anticancer peptides
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Active; Application No: 201815937281; Filed: Mar 27, 2018; Published: Feb 4, 2020; Earliest Priority: Mar 27, 2018; Granted: Feb 4, 2020
Other Published ID US10550155B2
This work is licensed under a Creative Commons Attribution 4.0 International License.