Shiva 10(1-18 AC)

General Information


DCTPep ID  DCTPep01616

Peptide Name   Shiva 10(1-18 AC)

Sequence  FAKKLAKKLKKLAKKLAK

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  FLAK peptides

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type LD50=190 µg/ml MTT assay 24 h Patent
SW480 Colon adenocarcinoma LD50=250 µg/ml MTT assay 24 h Patent
PC-3 Prostate carcinoma LD50=270 µg/ml MTT assay 24 h Patent
NCI-H1299 Lung large cell carcinoma LD50=320 µg/ml MTT assay 24 h Patent
BMKC Skin carcinoma LD50=445 µg/ml MTT assay 24 h Patent
BMKC Skin carcinoma LD50=445 µg/ml MTT assay 24 h Patent
HeLa Human papillomavirus-related endocervical adenocarcinoma LD50=570 µg/ml MTT assay 24 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01616

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C99H183N27O19

Absent amino acids  CDEGHIMNPQRSTVWY

Theoretical pI  10.90

Acidic residues  0

Basic residues  9

Polar residues  0

Molecular weight (Average)  2055.71

Molecular weight (Monoisotopic)  2054.42

Common amino acids  K

Net charge  9

Instability index (II)  -14.14

Aliphatic index  108.89

Grand average of hydropathicity (GRAVY)  -0.550

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US2005/0209157A1

Patent Title  Short bioactive peptides and methods for their use

Other Iinformation  Patent Application; Family: 1s / 24ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 13618605; Filed: May 24, 2005; Published: Sep 22, 2005; Earliest Priority: Mar 28, 2001

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.