Peptide Libraray

SHIVA 11[(1-16)ME(2-9]-COOH

General Information

DCTPep ID DCTPep01622

Peptide Name SHIVA 11[(1-16)ME(2-9]-COOH

Sequence FAKKLAKKLKKLAKKLIGAVLKV

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin FLAK peptides

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SW480	Colon adenocarcinoma	LD50=120 µg/ml	MTT assay	24 h	Patent
HeLa	Human papillomavirus-related endocervical adenocarcinoma	LD50=180 µg/ml	MTT assay	24 h	Patent
PC-3	Prostate carcinoma	LD50=28 µg/ml	MTT assay	24 h	Patent
NCI-H1299	Lung large cell carcinoma	LD50=54 µg/ml	MTT assay	24 h	Patent
BMKC	Skin carcinoma	LD50=94 µg/ml	MTT assay	24 h	Patent
BMKC	Skin carcinoma	LD50=94 µg/ml	MTT assay	24 h	Patent
MCF-7	Invasive breast carcinoma of no special type	LD50=95 µg/ml	MTT assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01622

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C123H226N32O24

Absent amino acids CDEHMNPQRSTWY

Theoretical pI 10.90

Acidic residues 0

Basic residues 9

Polar residues 1

Molecular weight (Average) 2537.35

Molecular weight (Monoisotopic) 2535.74

Common amino acids K

Net charge 9

Instability index (II) -19.97

Aliphatic index 144.35

Grand average of hydropathicity (GRAVY) 0.278

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US2005/0209157A1

Patent Title Short bioactive peptides and methods for their use

Other Iinformation Patent Application; Family: 1s / 24ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 13618605; Filed: May 24, 2005; Published: Sep 22, 2005; Earliest Priority: Mar 28, 2001

Other Published ID Not available