FLAK 26 Ac
General Information
DCTPep ID DCTPep01630
Peptide Name FLAK 26 Ac
Sequence FAKKLAKLAKKLAKLAL
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin FLAK peptides
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
SW480 | Colon adenocarcinoma | LD50=100 µg/ml | MTT assay | 24 h | Patent |
MCF-7 | Invasive breast carcinoma of no special type | LD50=105 µg/ml | MTT assay | 24 h | Patent |
NCI-H1299 | Lung large cell carcinoma | LD50=127 µg/ml | MTT assay | 24 h | Patent |
BMKC | Skin carcinoma | LD50=140 µg/ml | MTT assay | 24 h | Patent |
BMKC | Skin carcinoma | LD50=140 µg/ml | MTT assay | 24 h | Patent |
HeLa | Human papillomavirus-related endocervical adenocarcinoma | LD50=170 µg/ml | MTT assay | 24 h | Patent |
PC-3 | Prostate carcinoma | LD50=66 µg/ml | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01630
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H163N23O18
Absent amino acids CDEGHIMNPQRSTVWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1855.43
Molecular weight (Monoisotopic) 1854.25
Common amino acids K
Net charge 6
Instability index (II) -10.56
Aliphatic index 144.12
Grand average of hydropathicity (GRAVY) 0.435
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2005/0209157A1
Patent Title Short bioactive peptides and methods for their use
Other Iinformation Patent Application; Family: 1s / 24ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 13618605; Filed: May 24, 2005; Published: Sep 22, 2005; Earliest Priority: Mar 28, 2001
Other Published ID Not available