Peptide Libraray

CA(1-& HECATE(11/23)

General Information

DCTPep ID DCTPep01727

Peptide Name CA(1-& HECATE(11/23)

Sequence KWKLFKKALKKLKKALKKAL

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin FLAK peptides

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
BMKC	Skin carcinoma	LD50=100 µg/ml	MTT assay	24 h	Patent
MCF-7	Invasive breast carcinoma of no special type	LD50=11 µg/ml	MTT assay	24 h	Patent
HeLa	Human papillomavirus-related endocervical adenocarcinoma	LD50=130 µg/ml	MTT assay	24 h	Patent
PC-3	Prostate carcinoma	LD50=18 µg/ml	MTT assay	24 h	Patent
NCI-H1299	Lung large cell carcinoma	LD50=52 µg/ml	MTT assay	24 h	Patent
SW480	Colon adenocarcinoma	LD50=54 µg/ml	MTT assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01727

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C119H211N31O21

Absent amino acids CDEGHIMNPQRSTVY

Theoretical pI 10.95

Acidic residues 0

Basic residues 10

Polar residues 0

Molecular weight (Average) 2412.18

Molecular weight (Monoisotopic) 2410.64

Common amino acids K

Net charge 10

Instability index (II) -19.24

Aliphatic index 112.50

Grand average of hydropathicity (GRAVY) -0.635

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.280

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US2005/0209157A1

Patent Title Short bioactive peptides and methods for their use

Other Iinformation Patent Application; Family: 1s / 24ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 13618605; Filed: May 24, 2005; Published: Sep 22, 2005; Earliest Priority: Mar 28, 2001

Other Published ID Not available