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pep1
General Information
DCTPep ID DCTPep01760
Peptide Name pep1
Sequence EARPALLTSRLRFIPK
Sequence Length 16
UniProt ID O14746
PubChem CID Not available
Origin Not available
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| AsPC-1 | Pancreatic ductal adenocarcinoma | Significantly inhibiting fibrosis of AsPC1 Cell | Xenograft experiments | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01760
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C85H146N26O21
Absent amino acids CDGHMNQVWY
Theoretical pI 11.71
Acidic residues 1
Basic residues 4
Polar residues 2
Molecular weight (Average) 1868.26
Molecular weight (Monoisotopic) 1867.12
Common amino acids LR
Net charge 3
Instability index (II) 55.73
Aliphatic index 110.00
Grand average of hydropathicity (GRAVY) -0.206
Half Life
1 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2017/0028035A1
Patent Title Peptide Having Fibrosis Inhibitory Activity and Composition Containing Same
Other Iinformation Patent Application; Family: 14s / 14ex; Family Jurisdictions: CN, EP, US, JP, KR, WO; Legal Status: Active; Application No: 201515303370; Filed: Apr 10, 2015; Published: Feb 2, 2017; Earliest Priority: Apr 11, 2014; Granted: Apr 10, 2018
Other Published ID CN106456697A CN106456697B EP3130345A1 EP3130345A4 EP3130345B1 JP2017513941A JP2018193384A JP6420459B2 JP6748155B2 KR20160135358A US2018207241A1 US9937240B2 WO2015156649A1
This work is licensed under a Creative Commons Attribution 4.0 International License.