This work is licensed under a Creative Commons Attribution 4.0 International License.
IDP-intwtLN10
General Information
DCTPep ID DCTPep01781
Peptide Name IDP-intwtLN10
Sequence RRRRRRRAAKVVILKKATEYVHS
Sequence Length 23
UniProt ID P04198 Q61976 P18444 P24793 P26014
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
ACP
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| 12O53, epithelial (glioblastoma, GMB), from surgical specimens from patients | Glioblastoma | EC50>100 μM | CYTELL assay | 72-96 h | Patent |
| RG1, epithelial (glioblastoma, GMB), from surgical specimens from patients | Glioblastoma | EC50>100 μM | CYTELL assay | 72-96 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01781
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C123H221N49O29
Absent amino acids CDFGMNPQW
Theoretical pI 12.13
Acidic residues 1
Basic residues 11
Polar residues 3
Molecular weight (Average) 2850.42
Molecular weight (Monoisotopic) 2848.73
Common amino acids R
Net charge 10
Instability index (II) 168.36
Aliphatic index 84.78
Grand average of hydropathicity (GRAVY) -1.148
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.523
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2020/0157150A1
Patent Title Anticancer Peptides
Other Iinformation Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017
Other Published ID AU2018311129A1 CA3071601A1 CN111436200A EP3661947A1 JP2020529429A KR20200032730A WO2019025432A1
This work is licensed under a Creative Commons Attribution 4.0 International License.