LH01

General Information


DCTPep ID  DCTPep01787

Peptide Name   LH01

Sequence  RVKLVNLGFATLREHVP

Sequence Length  17

UniProt ID  Q06234  Q02067  P19359  P50553 

PubChem CID  Not available

Origin  Synthetics

Type  Synthetic peptide

Classification

  

ACP



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
NCI-H187 Lung small cell carcinoma; Small cell lung cancer EC50>100 μM MTT assay Not available Patent
NCI-H82 Lung small cell carcinoma; Small cell lung cancer EC50>100 μM MTT assay Not available Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01787

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C89H149N27O22

Absent amino acids  CDIMQSWY

Theoretical pI  10.84

Acidic residues  1

Basic residues  4

Polar residues  3

Molecular weight (Average)  1949.33

Molecular weight (Monoisotopic)  1948.14

Common amino acids  LV

Net charge  3

Instability index (II)  20.95

Aliphatic index  125.88

Grand average of hydropathicity (GRAVY)  0.165

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US2020/0157150A1

Patent Title  Anticancer Peptides

Other Iinformation  Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017

Other Published ID  AU2018311129A1  CA3071601A1  CN111436200A  EP3661947A1  JP2020529429A  KR20200032730A  WO2019025432A1 




DCTPep is developed by Dr.Zheng's team.