Peptide Libraray

Synthetic peptide

General Information

DCTPep ID DCTPep01794

Peptide Name Synthetic peptide

Sequence KWKKLLKKPPPLLKKLLKKL

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SNU-601	Gastric signet ring cell adenocarcinoma	~20% survival rate at 10 µM	MTT assay	Not available	Patent
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	~60% survival rate at 10 µM	MTT assay	Not available	Patent
Calu-6	Lung adenocarcinoma	0% survival rate at 100 µM	MTT assay	Not available	Patent
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	0% survival rate at 100 µM	MTT assay	Not available	Patent
SNU-601	Gastric signet ring cell adenocarcinoma	0% survival rate at 100 µM	MTT assay	Not available	Patent
Calu-6	Lung adenocarcinoma	35% survival rate at 10 µM	MTT assay	Not available	Patent

Hemolytic Activity no haemolytic activity

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01794

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C122H218N30O21

Absent amino acids ACDEFGHIMNQRSTVY

Theoretical pI 10.90

Acidic residues 0

Basic residues 9

Polar residues 0

Molecular weight (Average) 2441.26

Molecular weight (Monoisotopic) 2439.69

Common amino acids K

Net charge 9

Instability index (II) -0.48

Aliphatic index 136.50

Grand average of hydropathicity (GRAVY) -0.710

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.253

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US6800727B2

Patent Title Peptides with increased + charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide and pharmaceutical compositions containing thereof

Other Iinformation Granted Patent; Family: 4s / 4ex; Family Jurisdictions: KR, US; Legal Status: Expired; Application No: 8141802; Filed: Feb 22, 2002; Published: Oct 5, 2004; Earliest Priority: Sep 19, 2001; Granted: Oct 5, 2004

Other Published ID KR100438416B1 KR20030024961A US6800727B2