SEQ ID NO: 18

General Information


DCTPep ID  DCTPep01795

Peptide Name   SEQ ID NO: 18

Sequence  LMXYLK

Sequence Length  6

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetics

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
ECV-304 Bladder carcinoma When the peptide concentrations were 1 nM, the Percent Cytotoxicity of the tumor was 11.0 ± 0.6 MTT assay 49 h Patent
KB Human papillomavirus-related endocervical adenocarcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 15.9 ± 1.0, 12.0 ± 0.3, 14.0 ± 1.0, 9.3 ± 0.4 MTT assay 48 h Patent
PA-1 Ovarian mixed germ cell tumor; Mixed germ cell tumor When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 18.3 ± 1.8, 22.8 ± 2.9, 21.8 ± 2.1, 20.3 ± 2.6 MTT assay 48 h Patent
PTC Papillary thyroid carcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 19.0 ± 1.6, 28.4 ± 1.0, 23.9 ± 2.9, 21.7 ± 1.5 MTT assay 48 h Patent
Mia PaCa-2 Pancreatic ductal adenocarcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 24.8 ± 2.0, 21.0 ± 2.6, 18.5 ± 0.6, 15.0 ± 0.6 MTT assay 48 h Patent
HEp-2 Human papillomavirus-related endocervical adenocarcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 47.0 ± 4.8, 38.3 ± 2.0, 35.8 ± 2.4, 32.9 ± 2.6 MTT assay 48 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Saa1, furanoid sugar amino acid

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US7060678B2

Patent Title  Peptides comprising furanoid sugar amino acids for the treatment of cancer

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Inactive; Application No: 63810703; Filed: Aug 8, 2003; Published: Jun 13, 2006; Earliest Priority: Aug 8, 2003; Granted: Jun 13, 2006

Other Published ID  US7060678B2 




DCTPep is developed by Dr.Zheng's team.