Gaegurin peptides SEQID NO: 2

General Information


DCTPep ID  DCTPep01807

Peptide Name   Gaegurin peptides SEQID NO: 2

Sequence  FLKWLFKWAKK

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Korean frog Rana rugosa

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
SK-N-DZ Neuroblastoma IC50=12.55 mM MTT assay 24 h Patent
A549 Lung adenocarcinoma IC50=14.53 mM MTT assay 24 h Patent
HCT 116 Colon carcinoma IC50=14.8 mM MTT assay 24 h Patent
A498 Renal cell carcinoma IC50=21.48 mM MTT assay 24 h Patent
SK-MEL-2 Melanoma IC50=22.25 mM MTT assay 24 h Patent
MKN45 Gastric adenocarcinoma IC50=22.51 mM MTT assay 24 h Patent
PC-3 Prostate carcinoma IC50=29.1 mM MTT assay 24 h Patent

Hemolytic Activity  non-hemolytic activity

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C79H115N17O12

Absent amino acids  CDEGHIMNPQRSTVY

Theoretical pI  10.48

Acidic residues  0

Basic residues  4

Polar residues  0

Molecular weight (Average)  1494.89

Molecular weight (Monoisotopic)  1493.89

Common amino acids  K

Net charge  4

Instability index (II)  -14.74

Aliphatic index  80.00

Grand average of hydropathicity (GRAVY)  -0.218

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 7.358

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US8076284B2

Patent Title  Analogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5

Other Iinformation  Granted Patent; Family: 9s / 9ex; Family Jurisdictions: EP, KR, US, WO, JP, CN; Legal Status: Active; Application No: 30102807; Filed: May 14, 2007; Published: Dec 13, 2011; Earliest Priority: May 16, 2006; Granted: Dec 13, 2011

Other Published ID  CN101443352A  EP2016094A1  EP2016094A4  JP2009537511A  KR100794499B1  KR20070111027A  US8076284B2  WO2007133033A1 




DCTPep is developed by Dr.Zheng's team.