Peptide Libraray

Gaegurin peptides SEQID NO: 2

General Information

DCTPep ID DCTPep01807

Peptide Name Gaegurin peptides SEQID NO: 2

Sequence FLKWLFKWAKK

Sequence Length 11

UniProt ID Not available

PubChem CID Not available

Origin Korean frog Rana rugosa

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SK-N-DZ	Neuroblastoma	IC50=12.55 mM	MTT assay	24 h	Patent
A549	Lung adenocarcinoma	IC50=14.53 mM	MTT assay	24 h	Patent
HCT 116	Colon carcinoma	IC50=14.8 mM	MTT assay	24 h	Patent
A498	Renal cell carcinoma	IC50=21.48 mM	MTT assay	24 h	Patent
SK-MEL-2	Melanoma	IC50=22.25 mM	MTT assay	24 h	Patent
MKN45	Gastric adenocarcinoma	IC50=22.51 mM	MTT assay	24 h	Patent
PC-3	Prostate carcinoma	IC50=29.1 mM	MTT assay	24 h	Patent

Hemolytic Activity non-hemolytic activity

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C79H115N17O12

Absent amino acids CDEGHIMNPQRSTVY

Theoretical pI 10.48

Acidic residues 0

Basic residues 4

Polar residues 0

Molecular weight (Average) 1494.89

Molecular weight (Monoisotopic) 1493.89

Common amino acids K

Net charge 4

Instability index (II) -14.74

Aliphatic index 80.00

Grand average of hydropathicity (GRAVY) -0.218

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 7.358

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US8076284B2

Patent Title Analogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5

Other Iinformation Granted Patent; Family: 9s / 9ex; Family Jurisdictions: EP, KR, US, WO, JP, CN; Legal Status: Active; Application No: 30102807; Filed: May 14, 2007; Published: Dec 13, 2011; Earliest Priority: May 16, 2006; Granted: Dec 13, 2011

Other Published ID CN101443352A EP2016094A1 EP2016094A4 JP2009537511A KR100794499B1 KR20070111027A US8076284B2 WO2007133033A1