Not available
General Information
DCTPep ID DCTPep01819
Peptide Name Not available
Sequence KAMKSIAKFIAK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
HeLa | Human papillomavirus-related endocervical adenocarcinoma | At the concentration of 40umol/L, 20umol/L and 5umol/L, the peptide can inhibit more than 80% of HeLa cells | MTT assay | Not available | Patent |
Hemolytic Activity 37% of red blood cells lysed at 200umol
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C62H110N16O14S1
Absent amino acids CDEGHLNPQRTVWY
Theoretical pI 10.48
Acidic residues 0
Basic residues 4
Polar residues 1
Molecular weight (Average) 1335.71
Molecular weight (Monoisotopic) 1334.81
Common amino acids K
Net charge 4
Instability index (II) 9.17
Aliphatic index 90.00
Grand average of hydropathicity (GRAVY) 0.225
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2009/015602A1
Patent Title Polypeptides Having Anticancer Activity
Other Iinformation Patent Application; Family: 10s / 10ex; Family Jurisdictions: WO, CN, EP, JP, US; Legal Status: Pending; Application No: 2008071804; Filed: Jul 30, 2008; Published: Feb 5, 2009; Earliest Priority: Jul 31, 2007
Other Published ID CN100590130C CN101168563A EP2184295A1 EP2184295A4 EP2184295B1 JP2010534689A JP5707594B2 US2010145012A1 US8207122B2