Peptide Libraray

Not available

General Information

DCTPep ID DCTPep01822

Peptide Name Not available

Sequence RKGWFKAMKSIAKFIAKEKLKEHL

Sequence Length 24

UniProt ID Not available

PubChem CID Not available

Origin Synthetics

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
JB6	Human anaplastic large cell lymphoma	When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.38.	MTT assay	Not available	Patent
CNE-1	Breast cancer	When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.58.	MTT assay	Not available	Patent
HNE-1	Nasopharyngeal carcinoma; Nasopharyngeal carcinoma	When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.6.	MTT assay	Not available	Patent
HeLa	Human papillomavirus-related endocervical adenocarcinoma	When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.9.	MTT assay	Not available	Patent
HT-1080	Fibrosarcoma	When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.97.	MTT assay	Not available	Patent

Hemolytic Activity 19% of red blood cells lysed at 200umol

Normal (non-cancerous) Cytotoxicity There were no notable toxic effects (within 48 hours) from subcutaneous injection into mice at 200 mg /kg body weight

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01822

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C136H223N37O30S1

Absent amino acids CDNPQTVY

Theoretical pI 10.39

Acidic residues 2

Basic residues 9

Polar residues 2

Molecular weight (Average) 2888.56

Molecular weight (Monoisotopic) 2886.68

Common amino acids K

Net charge 7

Instability index (II) -5.29

Aliphatic index 77.50

Grand average of hydropathicity (GRAVY) -0.608

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.904

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID WO2009/015602A1

Patent Title Polypeptides Having Anticancer Activity

Other Iinformation Patent Application; Family: 10s / 10ex; Family Jurisdictions: WO, CN, EP, JP, US; Legal Status: Pending; Application No: 2008071804; Filed: Jul 30, 2008; Published: Feb 5, 2009; Earliest Priority: Jul 31, 2007

Other Published ID CN100590130C CN101168563A EP2184295A1 EP2184295A4 EP2184295B1 JP2010534689A JP5707594B2 US2010145012A1 US8207122B2