This work is licensed under a Creative Commons Attribution 4.0 International License.
Not available
General Information
DCTPep ID DCTPep01824
Peptide Name Not available
Sequence YRPWGSGSGF
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MeW155 | Human melanoma | Peptide at 0.004 mM decreased the number of tumour cells to 65% of the control, a 0.02 mMol concentration decreased the number of cells to 49%, and a concentration of 0.1 mM was toxic to melanoma cell | Cell proliferation assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C52H68N14O14
Absent amino acids ACDEHIKLMNQTV
Theoretical pI 8.75
Acidic residues 0
Basic residues 1
Polar residues 6
Molecular weight (Average) 1113.2
Molecular weight (Monoisotopic) 1112.5
Common amino acids G
Net charge 1
Instability index (II) -1.9
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -0.830
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 6.279
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2009/015602A1
Patent Title Polypeptides Having Anticancer Activity
Other Iinformation Patent Application; Family: 10s / 10ex; Family Jurisdictions: WO, CN, EP, JP, US; Legal Status: Pending; Application No: 2008071804; Filed: Jul 30, 2008; Published: Feb 5, 2009; Earliest Priority: Jul 31, 2007
Other Published ID CN100590130C CN101168563A EP2184295A1 EP2184295A4 EP2184295B1 JP2010534689A JP5707594B2 US2010145012A1 US8207122B2
This work is licensed under a Creative Commons Attribution 4.0 International License.