This work is licensed under a Creative Commons Attribution 4.0 International License.
PIER4 (Tat-PIER1)
General Information
DCTPep ID DCTPep01831
Peptide Name PIER4 (Tat-PIER1)
Sequence GRKKRRQRRRPQ
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin AMPs
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SK-BR-3 | Breast adenocarcinoma | TAT-PIER1 dose-dependently killed a breast cancer cell line, SKBR3 | Flow cytometry | 12 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Hsp90
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C65H124N34O15
Absent amino acids ACDEFHILMNSTVWY
Theoretical pI 12.70
Acidic residues 0
Basic residues 8
Polar residues 1
Molecular weight (Average) 1621.92
Molecular weight (Monoisotopic) 1621
Common amino acids R
Net charge 8
Instability index (II) 227.68
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -3.650
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2013/134116A1
Patent Title Hsp90 Inhibitor for the Treatment of Cancer and Inflammatory Diseases
Other Iinformation Patent Application; Family: 1s / 1ex; Family Jurisdictions: WO; Legal Status: Pending; Application No: 2013028852; Filed: Mar 4, 2013; Published: Sep 12, 2013; Earliest Priority: Mar 5, 2012
Other Published ID US201261606551P20120305
This work is licensed under a Creative Commons Attribution 4.0 International License.