vitri D

General Information


DCTPep ID  DCTPep01842

Peptide Name   vitri D

Sequence  GLPVCGETCFTGSCYTPGCSCNWPVCNRN

Sequence Length  29

UniProt ID  Not available

PubChem CID  Not available

Origin  Viola tricolor

Type  Native peptide

Classification

  

Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
BEL-7402 Human papillomavirus-related endocervical adenocarcinoma IC50>10 µg/ml SRB assay 48 h 1

Hemolytic Activity  HRBCs: HC50=4.29 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01842

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys26

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C127H190N36O41S6

Absent amino acids  ADHIKMQ

Theoretical pI  5.96

Acidic residues  1

Basic residues  1

Polar residues  19

Molecular weight (Average)  3069.48

Molecular weight (Monoisotopic)  3067.22

Common amino acids  C

Net charge  0

Instability index (II)  44.29

Aliphatic index  33.45

Grand average of hydropathicity (GRAVY)  -0.028

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 7365
  Abs 0.1% (=1 g/l) 2.399, assuming all pairs of Cys residues form cystines
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 2.277, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20580652

Title  Isolation and characterization of cytotoxic cyclotides from Viola tricolor

Doi 10.1016/j.peptides.2010.05.004

Year  2010

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.