Peptide Libraray

CP-EPS8-NLS

General Information

DCTPep ID DCTPep01846

Peptide Name CP-EPS8-NLS

Sequence GRKKRRQRRRPQSKRKKNKKGKRK

Sequence Length 24

UniProt ID Not available

PubChem CID Not available

Origin Derived from the NLS of EPS8

Type Synthetic peptide

Classification

ACP Tumor active peptide EPS8/NLS inhibitors

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
KG-1a	Adult acute myeloid leukemia; Acute myeloid leukemia	~45%Cellular viability=105 µM	CCK-8 assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01846

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C128H246N60O29

Absent amino acids ACDEFHILMTVWY

Theoretical pI 12.85

Acidic residues 0

Basic residues 17

Polar residues 4

Molecular weight (Average) 3089.75

Molecular weight (Monoisotopic) 3087.96

Common amino acids K

Net charge 17

Instability index (II) 167.11

Aliphatic index 0.00

Grand average of hydropathicity (GRAVY) -3.533

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29357910

Title A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia

Doi 10.1186/s13046-018-0682-x

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available