DCTPep ID  DCTPep01851

Peptide Name   Amurin-2a

Sequence  FLPLLLAGLPSFLCLVFKKC

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Rana amurensis

Type  Native peptide

Hemolytic Activity  Horse erythrocytes: 50% Hemolysis=439.0 µM

Normal (non-cancerous) Cytotoxicity  HMEC-1: IC50=1545 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  Not available

Predicted Structure  DCTPep01851

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys14<--->Cys20

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  1.690

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 125
  Abs 0.1% (=1 g/l) 0.056, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 29366784

Title  Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues

Doi 10.1016/j.bbrc.2018.01.124

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available