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KFAK(4)
General Information
DCTPep ID DCTPep01863
Peptide Name KFAK(4)
Sequence KFAKKFAKKFAKKFAK
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 76% Killing=500µg/ml | MTS assay | 24 h | Patent |
Hemolytic Activity RBCs: 0.1%Hemolysis=250 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01863
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C96H154N24O17
Absent amino acids CDEGHILMNPQRSTVWY
Theoretical pI 10.85
Acidic residues 0
Basic residues 8
Polar residues 0
Molecular weight (Average) 1916.43
Molecular weight (Monoisotopic) 1915.19
Common amino acids K
Net charge 8
Instability index (II) 9.38
Aliphatic index 25.00
Grand average of hydropathicity (GRAVY) -0.800
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US7091185B2
Patent Title Periodic antimicrobial peptides
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Inactive; Application No: 78521004; Filed: Feb 24, 2004; Published: Aug 15, 2006; Earliest Priority: Feb 24, 2003; Granted: Aug 15, 2006
Other Published ID US2005187151A1
External Code
DBAASP ID DBAASPS_13354
This work is licensed under a Creative Commons Attribution 4.0 International License.