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LK(12)
General Information
DCTPep ID DCTPep01898
Peptide Name LK(12)
Sequence LKLKLKLKLKLKLKLKLKLKLKLK
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 60% Killing=500µg/ml | MTS assay | 24 h | Patent |
Hemolytic Activity RBCs: 35%Hemolysis=250 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01898
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C144H278N36O25
Absent amino acids ACDEFGHIMNPQRSTVWY
Theoretical pI 11.04
Acidic residues 0
Basic residues 12
Polar residues 0
Molecular weight (Average) 2914.02
Molecular weight (Monoisotopic) 2912.16
Common amino acids KL
Net charge 12
Instability index (II) -71.78
Aliphatic index 195.00
Grand average of hydropathicity (GRAVY) -0.050
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US7091185B2
Patent Title Periodic antimicrobial peptides
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Inactive; Application No: 78521004; Filed: Feb 24, 2004; Published: Aug 15, 2006; Earliest Priority: Feb 24, 2003; Granted: Aug 15, 2006
Other Published ID US2005187151A1
External Code
DBAASP ID DBAASPS_13399
This work is licensed under a Creative Commons Attribution 4.0 International License.