LK(12)

General Information


DCTPep ID  DCTPep01898

Peptide Name   LK(12)

Sequence  LKLKLKLKLKLKLKLKLKLKLKLK

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma 60% Killing=500µg/ml MTS assay 24 h Patent

Hemolytic Activity  RBCs: 35%Hemolysis=250 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01898

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C144H278N36O25

Absent amino acids  ACDEFGHIMNPQRSTVWY

Theoretical pI  11.04

Acidic residues  0

Basic residues  12

Polar residues  0

Molecular weight (Average)  2914.02

Molecular weight (Monoisotopic)  2912.16

Common amino acids  KL

Net charge  12

Instability index (II)  -71.78

Aliphatic index  195.00

Grand average of hydropathicity (GRAVY)  -0.050

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US7091185B2

Patent Title  Periodic antimicrobial peptides

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Inactive; Application No: 78521004; Filed: Feb 24, 2004; Published: Aug 15, 2006; Earliest Priority: Feb 24, 2003; Granted: Aug 15, 2006

Other Published ID  US2005187151A1 




DBAASP ID  DBAASPS_13399

DCTPep is developed by Dr.Zheng's team.