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Phylloseptin-Pha [A7K, V12I]
General Information
DCTPep ID DCTPep01929
Peptide Name Phylloseptin-Pha [A7K, V12I]
Sequence FLSLIPKAISAISALANHF
Sequence Length 19
UniProt ID A0A2I2KHV2
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-251MG | Astrocytoma | LD50=36.46 µM | MTT assay | Not available | 1 |
Hemolytic Activity Horse erythrocytes:50% Hemolysis=34.86µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01929
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C96H153N23O24
Absent amino acids CDEGMQRTVWY
Theoretical pI 8.76
Acidic residues 0
Basic residues 2
Polar residues 4
Molecular weight (Average) 2013.41
Molecular weight (Monoisotopic) 2012.15
Common amino acids A
Net charge 2
Instability index (II) 2.5
Aliphatic index 144.21
Grand average of hydropathicity (GRAVY) 1.216
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30774309
Title Structure-activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12627
This work is licensed under a Creative Commons Attribution 4.0 International License.