Phylloseptin-PHa [A7K, A8I, V12I, A16I]

General Information


DCTPep ID  DCTPep01931

Peptide Name   Phylloseptin-PHa [A7K, A8I, V12I, A16I]

Sequence  FLSLIPKIISAISALINHF

Sequence Length  19

UniProt ID  A0A2I2KHV2 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
U-251MG Astrocytoma LD50=9.547 µM MTT assay Not available 1

Hemolytic Activity  Horse erythrocytes:50% Hemolysis=2.766µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01931

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C102H165N23O24

Absent amino acids  CDEGMQRTVWY

Theoretical pI  8.76

Acidic residues  0

Basic residues  2

Polar residues  4

Molecular weight (Average)  2097.57

Molecular weight (Monoisotopic)  2096.24

Common amino acids  I

Net charge  2

Instability index (II)  -1.97

Aliphatic index  174.74

Grand average of hydropathicity (GRAVY)  1.500

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30774309

Title  Structure-activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

Doi 10.2147/DDDT.S191072

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_12629

DCTPep is developed by Dr.Zheng's team.