Peptide Libraray

Chionodracine [F1W; H4,15,17K; I9K; S11,21K]

General Information

DCTPep ID DCTPep01933

Peptide Name Chionodracine [F1W; H4,15,17K; I9K; S11,21K]

Sequence WFGKLYRGKTKVVKKVKGLLKG

Sequence Length 22

UniProt ID K4Q515

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SH-SY5Y		0% Killing=64 µM	CellTiter-Glo assay	Not available	1

Hemolytic Activity Human erythrocytes: 5% Hemolysis=3µM; 30% Hemolysis=50µM

Normal (non-cancerous) Cytotoxicity HUVEC: 3.84% Killing=64 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01933

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C122H205N33O25

Absent amino acids ACDEHIMNPQS

Theoretical pI 10.82

Acidic residues 0

Basic residues 8

Polar residues 6

Molecular weight (Average) 2534.18

Molecular weight (Monoisotopic) 2532.58

Common amino acids K

Net charge 8

Instability index (II) -35.49

Aliphatic index 92.73

Grand average of hydropathicity (GRAVY) -0.432

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.758

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30790604

Title Fish-derived antimicrobial peptides: Activity of a chionodracine mutant against bacterial models and human bacterial pathogens

Doi 10.1016/j.dci.2019.02.012

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_12632