Peptide Libraray

HEXIM1 (147-164)[K4,5,6,13,14,15R], BR-RRR12

General Information

DCTPep ID DCTPep01935

Peptide Name HEXIM1 (147-164)[K4,5,6,13,14,15R], BR-RRR12

Sequence QLGRRRHRRRPSRRRRHW

Sequence Length 18

UniProt ID O94992

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MDA-MB-231	Breast adenocarcinoma	25%Killing=100 µM	CellTox cytotoxicity assay	30 min	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HaCat: Not active up to 100 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01935

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C104H180N54O21

Absent amino acids ACDEFIKMNTVY

Theoretical pI 12.95

Acidic residues 0

Basic residues 12

Polar residues 2

Molecular weight (Average) 2522.92

Molecular weight (Monoisotopic) 2521.47

Common amino acids R

Net charge 12

Instability index (II) 284.1

Aliphatic index 21.67

Grand average of hydropathicity (GRAVY) -3.044

Half Life
0.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.180

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26734838

Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy

Doi 10.18632/oncotarget.6794

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_12675