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LTV-X13
General Information
DCTPep ID DCTPep01941
Peptide Name LTV-X13
Sequence LTVSPWYGCGMPFSTGKRIMLGE
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| OPM-2 | Plasma cell myeloma; Multiple myeloma | 0%Killing=50 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO-K1: 0%Killing=50 µM; HFF: 0%Killing=50 µM; WI-38: 0%Killing=50 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01941
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C114H176N28O31S3
Absent amino acids ADHNQ
Theoretical pI 8.20
Acidic residues 1
Basic residues 2
Polar residues 10
Molecular weight (Average) 2531
Molecular weight (Monoisotopic) 2529.22
Common amino acids G
Net charge 1
Instability index (II) 54.72
Aliphatic index 63.48
Grand average of hydropathicity (GRAVY) 0.152
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.762, assuming all pairs of Cys residues form cystines
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.762, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12683
This work is licensed under a Creative Commons Attribution 4.0 International License.