This work is licensed under a Creative Commons Attribution 4.0 International License.
LTV-PAP, LTV-KLA
General Information
DCTPep ID DCTPep01942
Peptide Name LTV-PAP, LTV-KLA
Sequence LTVSPWYGCGKLAKLAKKLAKLAK
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| OPM-2 | Plasma cell myeloma; Multiple myeloma | 78%Killing=10 µM; 100%Killing=50 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO-K1: 100%Killing=50 µM; HFF: 80%Killing=50 µM; WI-38: 55%Killing=50 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01942
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H207N31O28S1
Absent amino acids DEFHIMNQR
Theoretical pI 10.14
Acidic residues 0
Basic residues 6
Polar residues 6
Molecular weight (Average) 2588.24
Molecular weight (Monoisotopic) 2586.54
Common amino acids K
Net charge 6
Instability index (II) 5.47
Aliphatic index 110.00
Grand average of hydropathicity (GRAVY) 0.142
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.701, assuming all pairs of Cys residues form cystines
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.701, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12684
This work is licensed under a Creative Commons Attribution 4.0 International License.