1

General Information


DCTPep ID  DCTPep01945

Peptide Name   1

Sequence  ALFGILKKAFGKILTIFAGLPGVV

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma EC50=8.6 μM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01945

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C123H201N27O26

Absent amino acids  CDEHMNQRSWY

Theoretical pI  10.30

Acidic residues  0

Basic residues  3

Polar residues  5

Molecular weight (Average)  2474.11

Molecular weight (Monoisotopic)  2472.52

Common amino acids  GL

Net charge  3

Instability index (II)  19.51

Aliphatic index  150.42

Grand average of hydropathicity (GRAVY)  1.471

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30953170

Title  De novo design of anticancer peptides by ensemble artificial neural networks

Doi 10.1007/s00894-019-4007-6

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13109

DCTPep is developed by Dr.Zheng's team.