This work is licensed under a Creative Commons Attribution 4.0 International License.
1
General Information
DCTPep ID DCTPep01945
Peptide Name 1
Sequence ALFGILKKAFGKILTIFAGLPGVV
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | EC50=8.6 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01945
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C123H201N27O26
Absent amino acids CDEHMNQRSWY
Theoretical pI 10.30
Acidic residues 0
Basic residues 3
Polar residues 5
Molecular weight (Average) 2474.11
Molecular weight (Monoisotopic) 2472.52
Common amino acids GL
Net charge 3
Instability index (II) 19.51
Aliphatic index 150.42
Grand average of hydropathicity (GRAVY) 1.471
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30953170
Title De novo design of anticancer peptides by ensemble artificial neural networks
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13109
This work is licensed under a Creative Commons Attribution 4.0 International License.