This work is licensed under a Creative Commons Attribution 4.0 International License.
TsAP-1 [S7K][G10K][G11K][S12I][S14K]
General Information
DCTPep ID DCTPep01963
Peptide Name TsAP-1 [S7K][G10K][G11K][S12I][S14K]
Sequence FLSLIPKLVKKIIKAFK
Sequence Length 17
UniProt ID S6CWV8
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-251MG | Astrocytoma | IC50=2.9 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Horse erythrocytes: 28% Hemolysis=5 µM; Horse erythrocytes: 100% Hemolysis=20 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01963
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C100H172N22O19
Absent amino acids CDEGHMNQRTWY
Theoretical pI 10.60
Acidic residues 0
Basic residues 5
Polar residues 1
Molecular weight (Average) 1986.6
Molecular weight (Monoisotopic) 1985.32
Common amino acids K
Net charge 5
Instability index (II) -17.8
Aliphatic index 160.59
Grand average of hydropathicity (GRAVY) 0.859
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23770440
Title Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities
Doi 10.1016/j.biochi.2013.06.003
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
CancerPPD ID 3130
DBAASP ID DBAASPS_4299
This work is licensed under a Creative Commons Attribution 4.0 International License.