Peptide Libraray

TsAP-2 [G7K][G10K][G11K][S14K]

General Information

DCTPep ID DCTPep01964

Peptide Name TsAP-2 [G7K][G10K][G11K][S14K]

Sequence FLGMIPKLIKKLIKAFK

Sequence Length 17

UniProt ID S6D3A7

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
U-251MG	Astrocytoma	IC50=2.0 µM	MTT assay	24 h	1

Hemolytic Activity Horse erythrocytes: 28% Hemolysis=5 µM; Horse erythrocytes: 100% Hemolysis=20 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01964

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C99H170N22O18S1

Absent amino acids CDEHNQRSTVWY

Theoretical pI 10.60

Acidic residues 0

Basic residues 5

Polar residues 1

Molecular weight (Average) 1988.64

Molecular weight (Monoisotopic) 1987.28

Common amino acids K

Net charge 5

Instability index (II) -21.1

Aliphatic index 143.53

Grand average of hydropathicity (GRAVY) 0.747

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23770440

Title Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities

Doi 10.1016/j.biochi.2013.06.003

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_4300