TsAP-2 [G7K][G10K][G11K][S14K]

General Information


DCTPep ID  DCTPep01964

Peptide Name   TsAP-2 [G7K][G10K][G11K][S14K]

Sequence  FLGMIPKLIKKLIKAFK

Sequence Length  17

UniProt ID  S6D3A7 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
U-251MG Astrocytoma IC50=2.0 µM MTT assay 24 h 1

Hemolytic Activity  Horse erythrocytes: 28% Hemolysis=5 µM; Horse erythrocytes: 100% Hemolysis=20 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01964

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C99H170N22O18S1

Absent amino acids  CDEHNQRSTVWY

Theoretical pI  10.60

Acidic residues  0

Basic residues  5

Polar residues  1

Molecular weight (Average)  1988.64

Molecular weight (Monoisotopic)  1987.28

Common amino acids  K

Net charge  5

Instability index (II)  -21.1

Aliphatic index  143.53

Grand average of hydropathicity (GRAVY)  0.747

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23770440

Title  Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities

Doi 10.1016/j.biochi.2013.06.003

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_4300

DCTPep is developed by Dr.Zheng's team.