Magainin-2 [G3,18Dap; K4,10,11,14Dap; F5W; A15Dap; E19Dap; M21Nle]

General Information


DCTPep ID  DCTPep01973

Peptide Name   Magainin-2 [G3,18Dap; K4,10,11,14Dap; F5W; A15Dap; E19Dap; M21Nle]

Sequence  GIXXWLHSAXXFGXXFVXXIXNS

Sequence Length  23

UniProt ID  P11006 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
PANC-1 Pancreatic ductal adenocarcinoma EC50=61.4±1.7 µM(pH=7.4) WST-1 assay 24 h 1

Hemolytic Activity  Human kidney-derived GM cells: EC50=7.6±2.1 µM(pH=6); EC50=25.6±4.5 µM(pH=7.4)

Normal (non-cancerous) Cytotoxicity  HEK293: EC50=15.7±1.8 µM(pH=7.4)

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X(3/4/10/11/14/15/18/19)=Dap; X(21)=Nle

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31161686

Title  Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues

Doi 10.1002/cbic.201900226

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13422

DCTPep is developed by Dr.Zheng's team.