Peptide Libraray

G-K

General Information

DCTPep ID DCTPep01987

Peptide Name G-K

Sequence GIIKKIIKKIIKKK

Sequence Length 14

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	IC50>40 µM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: 0% Hemolysis=500 µM

Normal (non-cancerous) Cytotoxicity Human chondrocytes-articular cells Hca: 10% Killing=40 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01987

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C80H155N21O15

Absent amino acids ACDEFHLMNPQRSTVWY

Theoretical pI 10.78

Acidic residues 0

Basic residues 7

Polar residues 1

Molecular weight (Average) 1651.24

Molecular weight (Monoisotopic) 1650.2

Common amino acids K

Net charge 7

Instability index (II) -27.1

Aliphatic index 167.14

Grand average of hydropathicity (GRAVY) -0.050

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27644109

Title Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity

Doi 10.1021/acsami.6b08297

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_14061