G-K

General Information


DCTPep ID  DCTPep01987

Peptide Name   G-K

Sequence  GIIKKIIKKIIKKK

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia IC50>40 µM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: 0% Hemolysis=500 µM

Normal (non-cancerous) Cytotoxicity  Human chondrocytes-articular cells Hca: 10% Killing=40 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01987

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C80H155N21O15

Absent amino acids  ACDEFHLMNPQRSTVWY

Theoretical pI  10.78

Acidic residues  0

Basic residues  7

Polar residues  1

Molecular weight (Average)  1651.24

Molecular weight (Monoisotopic)  1650.2

Common amino acids  K

Net charge  7

Instability index (II)  -27.1

Aliphatic index  167.14

Grand average of hydropathicity (GRAVY)  -0.050

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27644109

Title  Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity

Doi 10.1021/acsami.6b08297

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_14061

DCTPep is developed by Dr.Zheng's team.