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G-V
General Information
DCTPep ID DCTPep01988
Peptide Name G-V
Sequence GIIKKIIKKIIKKV
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50=15 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 22% Hemolysis=300 µM; Human erythrocytes: 35% Hemolysis=500 µM
Normal (non-cancerous) Cytotoxicity Human chondrocytes-articular cells Hca: 50% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01988
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C79H152N20O15
Absent amino acids ACDEFHLMNPQRSTWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 1
Molecular weight (Average) 1622.2
Molecular weight (Monoisotopic) 1621.17
Common amino acids IK
Net charge 6
Instability index (II) -33.16
Aliphatic index 187.86
Grand average of hydropathicity (GRAVY) 0.529
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27644109
Title Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_14062
This work is licensed under a Creative Commons Attribution 4.0 International License.