General Information


DCTPep ID  DCTPep01989

Peptide Name  

Sequence  KLWKKIEKLIKKLLTSIR

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type EC50=47±3 µM Not available Not available 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis=236±13 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01989

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C107H192N28O23

Absent amino acids  ACDFGHMNPQVY

Theoretical pI  10.68

Acidic residues  1

Basic residues  7

Polar residues  2

Molecular weight (Average)  2238.88

Molecular weight (Monoisotopic)  2237.47

Common amino acids  K

Net charge  6

Instability index (II)  23.43

Aliphatic index  151.67

Grand average of hydropathicity (GRAVY)  -0.283

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.457

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29679519

Title  Designing Anticancer Peptides by Constructive Machine Learning

Doi 10.1002/cmdc.201800204

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_14291

DCTPep is developed by Dr.Zheng's team.