Peptide Libraray

General Information

DCTPep ID DCTPep01991

Peptide Name

Sequence DLFKQLQRLFLGILYCLYKIW

Sequence Length 21

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	EC50=47±4 µM	Not available	Not available	1

Hemolytic Activity Human erythrocytes：50% Hemolysis=132±16 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01991

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C132H201N29O28S1

Absent amino acids AEHMNPSTV

Theoretical pI 9.11

Acidic residues 1

Basic residues 3

Polar residues 4

Molecular weight (Average) 2674.29

Molecular weight (Monoisotopic) 2672.49

Common amino acids L

Net charge 2

Instability index (II) 39.42

Aliphatic index 148.57

Grand average of hydropathicity (GRAVY) 0.629

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 3.171, assuming all pairs of Cys residues form cystines
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 3.171, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29679519

Title Designing Anticancer Peptides by Constructive Machine Learning

Doi 10.1002/cmdc.201800204

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_14293