This work is licensed under a Creative Commons Attribution 4.0 International License.
General Information
DCTPep ID DCTPep01994
Peptide Name
Sequence KVWKIKKNIRRLLHGIKRGWKG
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | EC50=34±4 µM | Not available | Not available | 1 |
Hemolytic Activity Human erythrocytes: Not active up to 400 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01994
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C127H216N42O24
Absent amino acids ACDEFMPQSTY
Theoretical pI 12.32
Acidic residues 0
Basic residues 10
Polar residues 4
Molecular weight (Average) 2715.38
Molecular weight (Monoisotopic) 2713.7
Common amino acids K
Net charge 10
Instability index (II) 44.25
Aliphatic index 101.82
Grand average of hydropathicity (GRAVY) -0.968
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.051
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29679519
Title Designing Anticancer Peptides by Constructive Machine Learning
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_14296
This work is licensed under a Creative Commons Attribution 4.0 International License.