General Information


DCTPep ID  DCTPep01996

Peptide Name  

Sequence  AFLYRLTRQIRPWWRWLYKW

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type EC50=45.5±0.8 µM Not available Not available 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis=34±5 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01996

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C142H200N38O25

Absent amino acids  CDEGHMNSV

Theoretical pI  11.57

Acidic residues  0

Basic residues  5

Polar residues  3

Molecular weight (Average)  2839.39

Molecular weight (Monoisotopic)  2837.55

Common amino acids  RW

Net charge  5

Instability index (II)  53.67

Aliphatic index  83.00

Grand average of hydropathicity (GRAVY)  -0.670

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 24980
  Abs 0.1% (=1 g/l) 8.798

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29679519

Title  Designing Anticancer Peptides by Constructive Machine Learning

Doi 10.1002/cmdc.201800204

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_14298

DCTPep is developed by Dr.Zheng's team.