Peptide Libraray

SOR-C13

General Information

DCTPep ID DCTPep02006

Peptide Name SOR-C13

Sequence KEFLHPSKVDLPR

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Blarina brevicauda

Type Native peptide

Classification

TRPV6 antagonists

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	~18%Inhibition=100 µM	Promega CellTiter Blue assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism SOR-C13 and SOR-C27, derived from the C-terminus of soricidin, are high-affinity antagonists of human TRPV6 channels that are up-regulated in a number of cancers

Structure Information

PDB ID Not available

Predicted Structure DCTPep02006

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C72H116N20O19

Absent amino acids ACGIMNQTWY

Theoretical pI 8.60

Acidic residues 2

Basic residues 4

Polar residues 1

Molecular weight (Average) 1565.84

Molecular weight (Monoisotopic) 1564.87

Common amino acids KLP

Net charge 2

Instability index (II) 12.75

Aliphatic index 82.31

Grand average of hydropathicity (GRAVY) -0.915

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23554944

Title In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin

Doi 10.1371/journal.pone.0058866

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available