HAL-2/18
General Information
DCTPep ID DCTPep02012
Peptide Name HAL-2/18
Sequence GKWMSLLKHIWK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=14±2 µM | MTT assay | 48 h | 1 |
SW480 | Colon adenocarcinoma | IC50> 40 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Rat erythrocytes: IC50=87 μM
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=56±9 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C74H115N19O14S1
Absent amino acids ACDEFNPQRTVY
Theoretical pI 10.30
Acidic residues 0
Basic residues 4
Polar residues 2
Molecular weight (Average) 1526.91
Molecular weight (Monoisotopic) 1525.86
Common amino acids K
Net charge 4
Instability index (II) 87.98
Aliphatic index 97.50
Grand average of hydropathicity (GRAVY) -0.325
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 7.204
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22100226
Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Doi 10.1016/j.peptides.2011.11.002
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available