Peptide Libraray

Tritrp DiSu

General Information

DCTPep ID DCTPep02028

Peptide Name Tritrp DiSu

Sequence CVRRFPWWYPFLRRC

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin porcine cathelicidin peptide

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	IC50=12.3 µM	MTT assay	24h	1

Hemolytic Activity RBC: IC50=20.9 µM

Normal (non-cancerous) Cytotoxicity PBMC: IC50=26.2 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02028

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys1<--->Cys15

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C100H141N29O17S2

Absent amino acids ADEGHIKMNQST

Theoretical pI 10.72

Acidic residues 0

Basic residues 4

Polar residues 3

Molecular weight (Average) 2085.52

Molecular weight (Monoisotopic) 2084.05

Common amino acids R

Net charge 4

Instability index (II) 125.51

Aliphatic index 45.33

Grand average of hydropathicity (GRAVY) -0.380

Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 12615
Abs 0.1% (=1 g/l) 6.049, assuming all pairs of Cys residues form cystines
Ext. coefficient 12490
Abs 0.1% (=1 g/l) 5.989, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32126228

Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Doi 10.1016/j.bbamem.2020.183228

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available