MagaininF5W-Lys
General Information
DCTPep ID DCTPep02033
Peptide Name MagaininF5W-Lys
Sequence GIGKWLHSAKKFGKAFVGEIMNS
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin porcine cathelicidin peptide
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50=16.8 µM | MTT assay | 24h | 1 |
Hemolytic Activity RBC: IC50 ≥ 65 µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50 ≥ 65 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02033
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C116H181N31O29S1
Absent amino acids CDPQRTY
Theoretical pI 10.00
Acidic residues 1
Basic residues 5
Polar residues 7
Molecular weight (Average) 2505.96
Molecular weight (Monoisotopic) 2504.34
Common amino acids GK
Net charge 4
Instability index (II) 5.26
Aliphatic index 72.17
Grand average of hydropathicity (GRAVY) -0.078
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.195
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32126228
Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Doi 10.1016/j.bbamem.2020.183228
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available