Combi-2

General Information


DCTPep ID  DCTPep02035

Peptide Name   Combi-2

Sequence  FRWWHR

Sequence Length  6

UniProt ID  Not available

PubChem CID  Not available

Origin  porcine cathelicidin peptide

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia IC50 ≥ 65 µM MTT assay 24h 1

Hemolytic Activity  RBC: IC50 ≥ 65 µM

Normal (non-cancerous) Cytotoxicity  PBMC: IC50 ≥ 65 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C49H62N16O7

Absent amino acids  ACDEGIKLMNPQSTVY

Theoretical pI  12.00

Acidic residues  0

Basic residues  3

Polar residues  0

Molecular weight (Average)  987.13

Molecular weight (Monoisotopic)  986.5

Common amino acids  RW

Net charge  3

Instability index (II)  143.27

Aliphatic index  0.00

Grand average of hydropathicity (GRAVY)  -1.867

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 11.143

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 32126228

Title  Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Doi 10.1016/j.bbamem.2020.183228

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.