Peptide Libraray

EP5, Antimicrobial peptide OEP3121

General Information

DCTPep ID DCTPep02037

Peptide Name EP5, Antimicrobial peptide OEP3121

Sequence ACSAG

Sequence Length 5

UniProt ID P84182

PubChem CID Not available

Origin Eisenia fetida (Red wiggler worm)

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	60.20% apoptotic=1.5 mg/mL; 48.12% apoptotic=0.75 mg/mL	MTT assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Mechanisms of EP5 may be directed to enter into cells to influence duplication and synthesis. Another mechanism was to form multimers by the connection of disulfide bonds with cysteins, also to make a hole in the cell membrane and induce the contents out of the cell.

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title A novel antimicrobial vermipeptide family from earthworm Eisenia fetida

Doi 10.1016/j.ejsobi.2007.08.048

Year 2007

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

CancerPPD ID 4429

DBAASP ID DBAASPR_4320