PTPRJ pep-19.0

General Information


DCTPep ID  DCTPep02040

Peptide Name   PTPRJ pep-19.0

Sequence  CHHNLTHAC

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (Derived from PTPRJ pep-19)

Type  Synthetic peptide

Classification

  

Cancer targeted peptides PTPRJ agonist



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma 4 ± 1.4% Inhibition=160 μM Trypan blue assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  PTPRJ

Affinity  Not available

Mechanism  PTPRJ is a receptor-type protein tyrosine phosphatase whose expression is strongly reduced in the majority of investigated cancer cell lines and tumor specimens.It showed tumor suppressor activity in several models.



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C41H62N16O12S2

Absent amino acids  DEFGIKMPQRSVWY

Theoretical pI  7.00

Acidic residues  0

Basic residues  3

Polar residues  4

Molecular weight (Average)  1035.16

Molecular weight (Monoisotopic)  1034.42

Common amino acids  H

Net charge  3

Instability index (II)  120.24

Aliphatic index  54.44

Grand average of hydropathicity (GRAVY)  -0.356

Half Life 
  1.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 125
  Abs 0.1% (=1 g/l) 0.121, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23627474

Title  Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation

Doi 10.1021/cb3007192

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.