Temporin-1DRa [Aib1]

General Information


DCTPep ID  DCTPep02068

Peptide Name   Temporin-1DRa [Aib1]

Sequence  XFLGTLVNLAKKIL

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (Derived from Temporin-1DRa)

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HepG2 Hepatoblastoma LC50=40 µM CytoTox 96 non-radiactive cytotoxicity assay  1 h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis=60 µM

Normal (non-cancerous) Cytotoxicity  Mouse fibroblasts L929: LC50=17 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=AIB (Aminoisobutyric acid)

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17767978

Title  Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa

Doi 10.1016/j.peptides.2007.07.023

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_2336

DCTPep is developed by Dr.Zheng's team.