This work is licensed under a Creative Commons Attribution 4.0 International License.
GW-A4
General Information
DCTPep ID DCTPep02080
Peptide Name GW-A4
Sequence GAKALTKAATAFTKFYKTIW
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| AGS | Gastric adenocarcinoma | IC50=404 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>500 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02080
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C107H165N25O26
Absent amino acids CDEHMNPQRSV
Theoretical pI 10.18
Acidic residues 0
Basic residues 4
Polar residues 6
Molecular weight (Average) 2217.64
Molecular weight (Monoisotopic) 2216.24
Common amino acids A
Net charge 4
Instability index (II) 21.55
Aliphatic index 64.00
Grand average of hydropathicity (GRAVY) 0.095
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 3.152
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25380626
Title Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_2356
This work is licensed under a Creative Commons Attribution 4.0 International License.