Peptide Libraray

Alyteserin-2a [S7K, G11K]

General Information

DCTPep ID DCTPep02096

Peptide Name Alyteserin-2a [S7K, G11K]

Sequence ILGKLLKTAAKLLSNL

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic (Derived from Alyteserin-2a)

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	LC50=20 μM	CellTiter-Glo Luminescent Cell Viability assay	24 h	1

Hemolytic Activity Human erythrocytes: 50% Hemolysis=38 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02096

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C79H146N20O20

Absent amino acids CDEFHMPQRVWY

Theoretical pI 10.30

Acidic residues 0

Basic residues 3

Polar residues 4

Molecular weight (Average) 1696.15

Molecular weight (Monoisotopic) 1695.1

Common amino acids L

Net charge 3

Instability index (II) 0.19

Aliphatic index 183.12

Grand average of hydropathicity (GRAVY) 0.863

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22965637

Title Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent

Doi 10.1007/s00726-012-1395-7

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_4365