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BPC66
General Information
DCTPep ID DCTPep02112
Peptide Name BPC66
Sequence KLKKKFKLLQ
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | 4 ± 0.11% Growth inhibition=40 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 22 ± 4.0% Hemolysis=375 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Lys1<--->Gln10
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C62H112N16O12
Absent amino acids ACDEGHIMNPRSTVWY
Theoretical pI 10.60
Acidic residues 0
Basic residues 5
Polar residues 0
Molecular weight (Average) 1273.67
Molecular weight (Monoisotopic) 1272.86
Common amino acids K
Net charge 5
Instability index (II) 1.1
Aliphatic index 117.00
Grand average of hydropathicity (GRAVY) -0.880
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20708052
Title Antimicrobial cyclic decapeptides with anticancer activity
Doi 10.1016/j.peptides.2010.07.027
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_2903
This work is licensed under a Creative Commons Attribution 4.0 International License.