BPC158

General Information


DCTPep ID  DCTPep02152

Peptide Name   BPC158

Sequence  LLKKLFKKKQ

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Induce apoptosis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma 2 ± 0.13% Growth inhibition=40 μM MTT assay 48 h 1

Hemolytic Activity  Human erythrocytes: 9 ± 0.7% Hemolysis=375 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Leu1<--->Gln10

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C62H112N16O12

Absent amino acids  ACDEGHIMNPRSTVWY

Theoretical pI  10.60

Acidic residues  0

Basic residues  5

Polar residues  0

Molecular weight (Average)  1273.67

Molecular weight (Monoisotopic)  1272.86

Common amino acids  K

Net charge  5

Instability index (II)  0.67

Aliphatic index  117.00

Grand average of hydropathicity (GRAVY)  -0.880

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20708052

Title  Antimicrobial cyclic decapeptides with anticancer activity

Doi 10.1016/j.peptides.2010.07.027

Year  2010

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_3039

DCTPep is developed by Dr.Zheng's team.